Enteric-Coated Capsules: Engineered for Targeted Intestinal Release

In the realm of pharmaceuticals, enteric-coated capsules represent a sophisticated and specialized drug delivery system, distinguished by their precise target: the small intestine. This targeted mechanism is not merely a feature but a critical function that makes them indispensable in modern medicine.

The science behind this targeted release lies in a specialized polymer coating applied to the capsule shell. This coating is uniquely sensitive to pH levels. It remains stable and intact in the highly acidic environment of the stomach (typically pH 1.5–3.5), where it acts as a robust protective barrier. This is crucial because many active pharmaceutical ingredients (APIs) would be degraded by gastric acid, reducing their efficacy. Furthermore, direct release in the stomach can cause irritation to the gastric mucosa, leading to discomfort or adverse effects. The enteric coating effectively prevents this, ensuring the medication passes safely through the stomach.

Once the capsule travels from the stomach into the small intestine, the environment shifts dramatically. The pH here rises to a near-neutral or weakly alkaline range (typically pH 5–7). This change triggers the polymer coating to dissolve, allowing the capsule shell to disintegrate and release its contents. The small intestine is not only the primary site for nutrient and drug absorption but also a more suitable environment for releasing certain medications. For example, drugs like aspirin, which are known to irritate the stomach lining, can cause pain, ulcers, and other side effects if released directly in the stomach. Formulating them as enteric-coated capsules ensures their release in the intestine, significantly minimizing gastric irritation while guaranteeing optimal absorption and therapeutic outcomes.

Beyond protecting the stomach and the drug, this precise delivery system enhances the drug’s bioavailability. By ensuring the drug is released where it can be most effectively absorbed, the enteric coating prevents its premature breakdown or excretion, thereby maximizing its therapeutic potential.

In summary, the ability of enteric-coated capsules to dissolve precisely in the intestine is a testament to pharmaceutical innovation. It provides patients with a safer, more effective, and more comfortable treatment option, ensuring that medication reaches its intended target to deliver its full benefit.

For any inquiries about empty capsules, we welcome you to contact KornnacCaps.